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dihydrofolate reductase inhibitor Since the original group r
2018-10-31
Since the original group reported that VSELs can survive and differentiate to the hematopoietic lineage on OP9 cells, we sought to evaluate these candidate VSELs by the same assay, namely blood colony formation. When we cultured all the SYTOX-Blue-positive dihydrofolate reductase inhibitor in the C
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br Introduction Foundational cell fate
2018-10-31
Introduction Foundational cell fate reprogramming studies revealed ectopic expression of pluripotency-associated transcription factors (TF) OCT4, SOX2, KLF4, and c-MYC (OSKM) or OCT4, SOX2, NANOG, LIN28 (OSNL) in human fibroblasts (hFibs) cultured in pluripotent supportive conditions was sufficie
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The gene expression changes that occurred during the differe
2018-10-31
The gene expression changes that occurred during the differentiation process were consistent with our expectations of changes that must occur during neurogenesis. For example, there was a positive enrichment for genes involved in synaptogenesis and a negative enrichment for genes involved in progres
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br Experimental Procedures br Acknowledgments br Introductio
2018-10-31
Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem dopamine receptors (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI)
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While the role of TAp
2018-10-31
While the role of TAp53 (full-length p53) in CSC formation has been largely documented, the role of other p53 isoforms is still poorly described. The isoform Δ40p53, a highly expressed isoform in embryonic stem cells, has been proposed to control pluripotency by maintaining TAp53 in an inactive form
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However we discovered that miR regulated another
2018-10-31
However, we discovered that miR-291 regulated another Trithorax group protein, the H3K36 methyltransferase Ash1l. It was recently reported that H3K36me3 deposition at Hox loci occurs independently of transcription via the action of ASH1L and is sufficient to evict Polycomb (Miyazaki et al., 2013). W
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The first consistency check we performed was that the
2018-10-31
The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste
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The computed Nusselt number values
2018-10-30
The computed Nusselt number values obtained for the widely packed bundle (Fig. 7b) show a good agreement with the experimental data for all regimes [1]. Conclusion Acknowledgement The study was supported by the Russian Foundation for Basic Research (grant no. 14-08-00936). Introduction Nu
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br Methods Details on baseline associations
2018-10-30
Methods Details on baseline associations and the primary outcome of the trial have been described elsewhere (Joseph et al., 2014; Joseph, Casapia, & Montresor, 2015). Briefly: Development was assessed at the 12 and 24-month visits using the Bayley Scales of Infant and Toddler Development, Third
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The http www apexbt com media diy images
2018-10-30
The above-described results are mostly based on the assumption that partner, parental, and employment statuses influence the health status of men and women. However, there may be important selection effects other than the effect of social causation (Benzeval, 1998; Wyke & Ford, 1992). For example, t
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The observed protective effect of spatial access to temples
2018-10-30
The observed protective effect of spatial access to temples on adolescent continued alcohol use could be explained by the collective process of religion. Traditional temples are usually located in historical urban areas and reflect the retention of a territorial sense of place and local identity in
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In summary it is clear that the Late Cretaceous
2018-10-30
In summary, it is clear that the Late Cretaceous is a major episode of magmatic activities and the related large scale Sn–W mineralization distribute throughout the southeast Yunnan and northeast Vietnam. Combining the new data of this study and published igneous rocks and mineralization ages (Appen
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br Materials and methods br Results and discussion
2018-10-30
Materials and methods Results and discussion Conclusion Conflict of interest Acknowledgements We appreciate the help of staff from the University of South Florida Nanotechnology Research and Education Center, and also help of John Winskas and Surya Cheemalapati with device fabrication
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br Metodolog a Este trabajo
2018-10-30
Metodología Este trabajo busca demostrar el impacto de la ied en la distribución de empleos en los tres sectores de actividades de la economía mexicana. El análisis se realiza entre 1980 y 2014. Los datos provienen del inegi, Secretaría de Economía y Banxico. Para obtener resultados significativo
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BTL-104 In contrast with the traditional wage differential r
2018-10-30
In contrast with the traditional wage differential reason, Kwok and Leland (1982) proposed asymmetric information in the labor market as the reason of BTL-104 draining, by showing that wage differentials among countries is only a consequence and not cause of this phenomenon. On the other hand, Miyag
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