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El an lisis de Close merece una
2019-04-22
El análisis de Close merece una continuación. En efecto, la narrativa mexicana actual cuenta con otros autores de novelas de crímenes que se mantienen alejados de los tópicos necro-pornográficos misóginos y del gusto sensacionalista y moralista. En lo que sigue abogaremos por la inclusión de Alejand
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In humans the two primary bile acids CA and CDCA
2019-04-22
In humans, the two primary bile acids CA and CDCA make up approximately 70%–80% of the total bile interleukin pool. DCA is the major secondary bile acid, which may account for approximately 20% of the total bile acid pool. Among all bile acid species, the secondary bile acid LCA is highly toxic. LC
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Repurposing use of approved drugs for
2019-04-22
Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o
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br X Desde esa exigencia de una correcta
2019-04-22
X. Desde esa exigencia de una correcta hermeneusis receptora, la mecánica expositiva del misterio procederá, sin embargo, complicando esa primera alegoría que ya es el sacramento en sí y levantando, BI2536 partir de la transposición o metáfora que diseña (Cristo como pan, Cristo como vino de vida
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Al concluir las deliberaciones el congreso resolvi apoyar la
2019-04-22
Al concluir las deliberaciones, el congreso resolvió apoyar las gestiones de los gobiernos de “Argentina, Guatemala, Uruguay, Paraguay, Chile y Bolivia por su valiente postura de no dejarse intimidar, ni por las amenazas difamatorias en su contra, ni por las presiones y amenazas del ‘cartercomunismo
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Second political regime does very little to explain differen
2019-04-22
Second, political regime does very little to explain differences between countries. Rwanda, Congo (Brazzaville), and Tanzania have very similar child mortality rates (between 40 and 60 deaths per 1000 livebirths in 2014) to South Africa, Botswana, and Namibia despite the former countries being consi
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Interestingly it was reported that both salicylate and APAP
2019-04-22
Interestingly, it was reported that both salicylate and APAP activate p38 MAPK [13,14]. Furthermore, it is known that p38 MAPK is responsible for the phosphorylation of S538 in gp78. Phosphorylation of gp78 by p38 MAPK inhibited the degradation of mitofusin 1 (MFN1), a mitochondrial protein that bec
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melanotropin br Authors disclosure Mark Clemons received hon
2019-04-20
Authors\' disclosure Mark Clemons received honoraria for talks from Novartis and Amgen, research funding from Novartis. Case In September 2007 a 9½-year-old boy was diagnosed with a Ewing sarcoma (EWS-FL1 translocation positive) of the right scapula. MRI showed a tumor of 8.0×2.9 ×6.2cm locat
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Clinical history of patients with
2019-04-20
Clinical history of patients with surface osteosarcoma depends on its grade of malignancy. In low grade lesions and especially in cPOS, symptoms are most often of prolonged duration [3]. However, in HGSO and DPOS—especially when the dedifferentiation is synchronous—clinical history is not distinguis
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Autophagy can be generally divided into non selective bulk a
2019-04-20
Autophagy can be generally divided into non-selective bulk autophagy and selective autophagy. Non-selective autophagy breaks down proteins and organelles to provide the cell with nutrients in response to starvation. Selective autophagy removes damaged and excess organelles as well as protein parp in
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Expansion of access to HIV treatment is a global
2019-04-20
Expansion of access to HIV treatment is a global priority. In July, 2013, UNAIDS, in collaboration with WHO, the Global Fund to fight AIDS, Tuberculosis and Malaria, and the US President\'s Emergency Plan for AIDS Relief (PEPFAR) jointly issued which advocates for a worldwide treatment target of 15
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Long marginalised as a disorder confined to specific racial
2019-04-20
Long marginalised as a disorder confined to specific racial groups, sickle-cell disease is now assuming its rightful place as a major global public health problem. Most patients in the Americas, the Caribbean, and much of Europe have been of one racial group, which led to the common misconception th
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br India is rapidly becoming
2019-04-20
India is rapidly becoming urbanised. By 2030, around 40% of the country\'s population will live in urban areas. The extent to which India\'s health system can provide for this large and growing city-based population will determine the country\'s success in achieving universal health coverage and i
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Las formas transmisibles no del saber o de la sabidur
2019-04-20
“Las formas transmisibles, no del saber o de la sabiduría de un hombre, sino sobre todo su vida vivida —y esa es la materia con que se hacen historias— sólo son adquiridas al morir”, afirma Walter Benjamin. La muerte atraviesa toda la Historia verdadera: como motivo, como temor, como asombro o recue
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CLL associated HLH was first documented in
2019-04-20
CLL associated HLH was first documented in the form of a case series report which included six patients treated for CLL who subsequently developed the phagocytic syndrome months to years later.[7] As these cases occurred prior to publication of the 1991 HLH diagnostic guidelines, the authors postula
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