• Does hydroxylation of proline have a

  2019-12-11

  

  Does hydroxylation of proline have a specific role in the structure and function of the conotoxins? Several studies in the literature provide insights into the role of proline hydroxylation in the Conus peptides. The consequences of proline hydroxylation on oxidative folding and biological activity

• Herein we further established a dynamic DNA

  2019-12-11

  

  Herein, we further established a dynamic DNA self-assembly activated hemin-mimetic enzymes system by embedding DNA-hemin into an entropy-driven DNA-assembly for fluorescent biosensing. The entropy-driven dynamic DNA-assembly is one of the toehold-mediated isothermal strand displacement reactions, w

• br Introduction Epithelial mesenchymal transition

  2019-12-11

  

  Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial PF-03084014 lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation during embryo d

• The current study demonstrates a link

  2019-12-11

  

  The current study demonstrates a link between heme metabolism and mitochondrial Co-I, which deficits instigate abnormalities in the metabolism of heme and its downstream targets both in-vitro in patients and healthy subjects derived LCLs and in-vivo in brains of SZ-rat model. A further study of the

• Our study found a significant association between the degree

  2019-12-11

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P Trametinib DMSO solvate status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between

• In conclusion our study has demonstrated that

  2019-12-10

  

  In conclusion, our study has demonstrated that PGE2 stimulates expression of survivin in hepatocellular carcinoma cells. Although there are 4 subtypes of EP receptors, the EP1 receptor appears to be the predominant receptor that regulates PGE2-induced expression of survivin, mainly through trans-ac

• The contribution of local ETA and ETB

  2019-12-10

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor s1p in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies have shown

• The aim of this study was

  2019-12-10

  

  The aim of this study was to discover and characterize a novel thermostable gluten-specific prolyl endopeptidase suitable for use during the mashing step of beer production. Subsequently to express the recombinant enzyme in E.coli and to demonstrate degradation of immunogenic gluten derived peptides

• DDR plays a crucial role in regulating a wide variety

  2019-12-10

  

  DDR2 plays a crucial role in regulating a wide variety of fundamental cellular processes, including cell proliferation, differentiation, and adhesion [17], [28], [29], [30]. The authors revealed compromised cell migration in DDR2-silenced fibroblasts exposed to Ang II, most likely due to the loss of

• br Materials and methods br Results br

  2019-12-10

  

  Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated 2400 7 guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both LTC4 and LTD4[9]

• br Conflicts of interest br Acknowledgements

  2019-12-10

  

  Conflicts of interest Acknowledgements This work was supported by funding from Young Sanjin Scholars Distinguished Professor, the Aid Program for Innovation Research Team in Shanxi Agricultural University (CXTD201201), and the Special Fund for Agro-scientific Research in the Public Interest of

• br Conclusion CSF R may contribute to limitation of

  2019-12-10

  

  Conclusion CSF-1R may contribute to limitation of targeted therapies by providing EGFR-bypassing signals that support proliferation. Multi-kinase inhibitors such as cabozantinib are available, and agents targeting CSF-1R are in clinical trials, however, at present, as inhibitors of tumor-associat

• Of note CS associated lung injury is closely linked

  2019-12-10

  

  Of note, CS-associated lung injury is closely linked with augmented influx of macrophages that subsequently intensify the lung injury [34,47] while macrophage depletion alleviates CS-induced pulmonary inflammation via reducing cytokines and chemokine production in BALF [48]. Similar effect has been

• egfr pathway br Experimental section br Results br Discussio

  2019-12-10

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised egfr pathway did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient

• RQ What are the different factors that influence the

  2019-12-10

  

  RQ2: What are the different factors that influence the decision to choose among different component origins? In total eleven factors grouped into three high-level themes that influence the decision to choose a component origin were identified. The project metrics factors are: time, cost, effort and

15197 records 862/1014 page Previous Next First page 上5页 861862863864865 下5页 Last page