• br Gap junctions hemichannels and

  2022-05-19

  

  Gap junctions, hemichannels and connexins: Molecular characteristics and function Cell-to-cell communication is of extreme importance in tissue homeostasis, which is maintained by transmission of regulatory signals (Fig. 1). Intercellular communication via gap junctions (GJs) represents one of th

• In this study we describe the expression of galr

  2022-05-19

  

  In this study, we describe the expression of galr2a and galr2b in zebrafish embryos using whole-mount in situ RNA hybridization. To further analyze the distribution of GALR2b and its interactions with galanin, we generated Tg(galr2b:egfp) zebrafish, which express EGFP under the control of a galr2b p

• In the thoracic spinal cord neither glacial

  2022-05-19

  

  In the thoracic spinal cord, neither glacial acetic c14ɑ demethylase nor HBO2 had an effect on nNOS expression or expression of the phosphorylated β3 subunit of the GABAA receptor. This result was not unexpected due to the preponderance of nociceptive signaling in the lumbar versus thoracic spinal

• br Results br Discussion Glucose homeostasis is

  2022-05-19

  

  Results Discussion Glucose homeostasis is regulated by a complex and intricate signaling network involving multiple organs. The BA nuclear receptor FXR is integrated into this regulatory network and participates in glucose handling and metabolism. Intestinal FXR favors glucose acetylcholine ch

• Accumulating evidence suggests an important role

  2022-05-19

  

  Accumulating evidence suggests an important role for endothelin ETB receptors in renal homeostasis. ETB receptors promote vasodilation, natriuresis, and diuresis (Davenport and Maguire, 2011) and maintain renal perfusion via counterbalancing the effects of vasoconstrictors and regulation of water re

• The combination of HIV antigen and

  2022-05-19

  

  The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window Antagonist G for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo assay has

• In the Joint United Nations Program on

  2022-05-19

  

  In 2015, the Joint United Nations Program on HIV/AIDS (UNAIDS) proposed that by 2020, 90% of people living with HIV should be aware of their HIV status, as the first part of 90-90-90 strategy to end AIDS epidemic. Early detection of HIV allows initiating care for proper treatment, which impacts in m

• br Conclusions Histone acetylation deacetylation is a

  2022-05-19

  

  Conclusions Histone acetylation/deacetylation is a major epigenetic mechanism implicated in the regulation of transcription and various biological processes such as development and gametogenesis from plants to vertebrates. However, despite being well characterized in zebrafish, acetyltransferase

• Finally life expectancy was strongly reduced in

  2022-05-19

  

  Finally, life expectancy was strongly reduced in STK4-deficient patients. Even in those patients who received haematopoietic stem cell transplantation, the majority of patients died due to transplantation-related complications, raising the question whether MST1 expressed in nonhaematopoietic tissue

• Recently it has been found that treatment

  2022-05-19

  

  Recently, it has been found that treatment of human phagocytic L 012 sodium salt or microvascular endothelial cells with NO donors inhibited the O2− generating capacity of NADPH oxidase [[8], [9], [10], [11]], which may involve down-regulation or S‑nitrosylation of the p47phox subunit (a cytosolic

• br Materials and methods br Results br Discussion Directly

  2022-05-18

  

  Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic lasofoxifene is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor in prostate cancer. Howe

• GPR belongs to the G protein coupled receptor family

  2022-05-18

  

  GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty Gemcitabine HCl (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone m

• Continuing studies of endocannabinoid ligands at GPR reveal

  2022-05-18

  

  Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort

• br Conflicts of interest br Introduction Antiretroviral ther

  2022-05-18

  

  Conflicts of interest Introduction Antiretroviral therapy (ART) is effective in reducing mortality (Detels et al., 1998), and preventing mother-to-child transmission (MTCT) (CDC, 1994, Connor et al., 1994) and sexual transmission of HIV (Cohen et al., 2011). However, the optimal time to start

• br Sodium glucose co transporter inhibitors SGLT

  2022-05-18

  

  Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are the latest class of non-insulin glucose-lowering agents that facilitate glycaemic control by inhibiting renal glucose reabsorption, thus promoting glycosuria. Canagliflozin, dapagliflozin, and empagliflozin are the three commonly used agents

15549 records 412/1037 page Previous Next First page 上5页 411412413414415 下5页 Last page