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WM-2474 NCSs are helical proteins containing four EF
2022-08-03
NCSs are α-helical proteins containing four EF-hand motifs with EF1 being incapable of Ca-binding throughout the family (atomic-resolution structure was firstly resolved for recoverin [5]; for review on NCS structure, see [6]). Some of the NCS proteins (i.e. recoverin and KChIP3) have two while othe
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Taken together specific antibodies and SR SIM used in
2022-08-02
Taken together, specific TBCA and SR-SIM used in the study helped uniquely visualize the distribution of lymphocytes and macrophages with their molecular expression in human cochleae. Using SR-SIM, we verified that resident IBA1-positive macrophages are widely distributed in human cochlea (Liu et a
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br Introduction Prostate cancer is the most commonly diagnos
2022-08-02
Introduction Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in men in the United States, accounting for about 30,000 cancer deaths annually [1]. Epidemiological studies that show geographical variations in prostate cancer incidence and mortalit
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To evaluate SLC A abundance
2022-08-02
To evaluate SLC45A1 abundance after transfection, we performed western blots. Transfected COS-7 SB408124 synthesis were lysed and separated for membrane fraction. Equal amounts of proteins from membrane fractions were resolved by SDS-PAGE, transferred to a nitrocellulose filter, and immunoblotted w
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Ghrelin is mostly known for its orexigenic
2022-08-02
Ghrelin is mostly known for its orexigenic properties, whereas the role of DAG on feeding is controversial with studies claiming an orexigenic, anorexigenic or no effect (Inhoff et al, 2009, Toshinai et al, 2006). One of these studies was that of Toshinai and colleagues, who found a link between the
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We have previously shown in the same
2022-08-02
We have previously shown in the same time frame reported here (10 min) that AG was not degraded into DAG [29] and that the half-life of AG in human serum is ∼10 min [49]. However, we cannot rule out in this study that there is not breakdown to DAG that could contribute to the levels of 125I-ghrelin
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DY131 In order to test the influence
2022-08-02
In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to DY131 incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to the final composition in the f
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SCPNs and CPNs exhibit similar strength of
2022-08-02
SCPNs and CPNs exhibit similar strength of electrical coupling (Maruoka et al., 2017) and had similar membrane properties (Experimental Procedures), and showed no significant difference in amplification and synchronization (Figs. 2E and 3C). However, a subset of CPNs exhibit very strong electrical c
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br Discussion br Author Contributions br Alzheimer s disease
2022-08-02
Discussion Author Contributions Alzheimer’s disease (AD) is an age-related, chronically progressive neurodegenerative disorder affecting more than 35million people worldwide and an estimated 5.5million in the US. Current marketed drugs such as acetylcholinesterase inhibitors and the NMDA ant
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By association a possible mechanism which may underlie
2022-08-02
By association, a possible mechanism which may underlie the progression of seizures is long-term potentiation (LTP). Indeed, LTP shares many common mechanisms with seizures activity both anatomically and physiologically, and has been implicated as a mechanism of acute epileptogenesis (Wasterlain et
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Galanin a amino acid peptide was first
2022-08-02
Galanin, a 29/30-amino-acid peptide, was first isolated in 1983 from porcine intestine by Tatemoto and collaborators [70]. It is widely distributed throughout the central and peripheral nervous systems as well as other tissues. It is involved in a wide range of physiological functions, such as modul
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limonin br Materials Aspergillus oryzae GS U mg solid was
2022-08-02
Materials Aspergillus oryzae βGS (8.4 U mg−1 solid) was obtained from Sigma-Aldrich Chemicals Co. (USA). o-Nitrophenyl β-d-galactopyranoside (ONPG), sodium carbonate, zinc chloride, manganese chloride, calcium chloride and potassium chloride were procured from Sisco Research Laboratories (SRL), M
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br Summary The presented results of the
2022-08-02
Summary The presented results of the analysis of the unfolding of G-quadruplex and i-motif, which may appear within the telomeric DNA region, led to several important conclusions. Namely, determination of the work necessary to unfold of these structures, in biased molecular dynamics involving ste
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NB-598 receptor br The bile acid farnesoid X receptor FXR
2022-08-02
The “bile acid” farnesoid X receptor (FXR) The Farnesoid X Receptor (FXR) is a ligand-activated nuclear receptor belonging to the Nuclear Receptor superfamily of transcription factors exploiting various crucial functions in mammalian physiology, including reproduction, development and metabolism
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The recent identification of new
2022-08-02
The recent identification of new mechanisms for triggering ferroptosis, by compounds termed FIN56 and FINO2, provided new insights into regulation of ferroptosis. FINO2 acts through a distinct mechanism: it promotes lipid peroxidation by oxidizing iron and indirectly inactivating GPX4 [180]. FIN56 w
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