• br Excitatory amino acid transporter mediated glutamate tran

  2022-09-16

  

  Excitatory amino Tacalcitol transporter-mediated glutamate transport Early studies detailing the presence of uptake systems capable of transporting glutamate and aspartate into neurons and glia represented a critical step in the overall task of demonstrating that l-glutamate was indeed an endoge

• It is important to control hyperglycaemia because it

  2022-09-16

  

  It is important to control hyperglycaemia because it can contribute to serious complications. Hyperglycaemia can be managed by maintaining stable blood glucose levels inside the normal range. This can be achieved by various strategies such as diet, medications and exercise (O’Keefe & Bell, 2007). Se

• Communication through GJ channels is regulated

  2022-09-15

  

  Communication through GJ channels is regulated at different levels and includes GJ plaque internalization into a single cell. Those vesicles contain the membrane of both cells and th assembled Cx43. The C-terminal domain of Cx43 interacts with different peptides and proteins. However, the internaliz

• To meet the requirement of ferroptosis

  2022-09-15

  

  To meet the requirement of ferroptosis-based therapy, a couple of small molecule drugs and nanomaterials were introduced to the design of ferroptosis inducers, separately. As we know, iron is a key regulator of ferroptosis. When small molecule drugs are employed to induce ferroptosis, the endogenous

• Besides its carcinogenic role WTAP was also discovered to

  2022-09-15

  

  Besides its carcinogenic role, WTAP was also discovered to participate in several physical processes in normal cells. As previously reported, WTAP was involved in cell proliferation, survival, apoptosis [7,29,30], eye development [8] and embryonic development [7] owing to its complex function in tra

• br Conflict of interests br

  2022-09-15

  

  Conflict of interests Acknowledgements This work was supported by the National Institutes of Health grants HD058577 and ES01678 to Kirill Kiselyov. We thank Sreeram Ravi for technical support. We also thank Mike Myers at the University of Pittsburgh Cancer Institute Flow Cytometry Facility.

• Management of HIV treatment with HIV PIs

  2022-09-15

  

  Management of HIV-1 treatment with HIV PIs can be complicated due to wide inter-patient variability in AP-III-a4 synthesis levels. In certain scenarios, therapeutic drug monitoring (TDM) has been recommended as a useful approach to individualize therapy for HIV-infected patients [[9], [10], [11], [

• The concentration of rapamycin that gave half maximal

  2022-09-15

  

  The concentration of rapamycin that gave half-maximal induction of the expression of HO-1 and Prx-1 mRNA in normal hepatocytes was 0.05 μM, with maximal induction at about 0.1 μM rapamycin. While, at rapamycin concentrations higher than 0.1 μM, the degree of enzyme induction decreased, elevated expr

• While PLGA implants could be beneficial for regenerative ang

  2022-09-09

  

  While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they medetomidine receptor could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, whic

• As natural ligands of GPR several long

  2022-09-09

  

  As natural ligands of GPR120, several long chain polyunsaturated fatty acids (Lc-PUFAs) have been demonstrated to modulate the 3T3-L1 adipogenic differentiation. However, the effects of the Lc-PUFAs are inconclusive. DHA is shown to inhibit, promote or even not affect the differentiation of preadipo

• To effectively evaluate prospective mechanisms by which chro

  2022-09-09

  

  To effectively evaluate prospective mechanisms by which chronic HIV infection induces pulmonary fibrotic changes in humans, we confirmed that predisposition to fibrotic change in older individuals could be mimicked in a mouse model. Hydroxyproline is a nonessential amino RNase Inhibitor required for

• Experiments conducted on the human parasite Leishmania major

  2022-09-09

  

  Experiments conducted on the human parasite Leishmania major has shown that specific parasitic antigens are involved in steering the immune responses to “protective” as opposed to “disease” state (Reiner et al., 1993; Reiner and Locksley, 1995; and Sjölander et al., 1998) and that antigenic composit

• To verify the feasibility of the proposed

  2022-09-09

  

  To verify the feasibility of the proposed method, EIS is firstly adopted to study the modification processes of the electrode. As shown in Fig. 1A, the nyquist plot of bare gold electrode exhibits a straight line, which indicates a fast charge transfer process (curve a). After modified with probe a,

• Interestingly mGlu and mGlu receptors differ notably

  2022-09-09

  

  Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 2001

• ICH induced striatal lesion produced

  2022-09-09

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Aprotinin transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (

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