• Another contributor for the G M arrest in A

  2023-04-14

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks Pentamidine G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al., 2015)

• Although TP status has been shown to play a role

  2023-04-14

  

  Although TP53 status has been shown to play a role in ATR inhibition and platinum resistance [7], [27], [38], in inhibition of ATM and sensitivity to IR [39], and in the activation of Chk1 and Chk2 [3], [4], ATM and ATR signaling can occur through the p38MAPK/MK2 pathway in p53-deficient Disulfiram

• br Conclusion br Acknowledgements br Introduction Synapses

  2023-04-14

  

  Conclusion Acknowledgements Introduction Synapses are the fundamental elements of neuronal networks that enable the processing, encoding, and retrieval of information in the brain, and pathological disruptions in synapse structure are broadly held to underlie the development of neurological

• Autophagy is a self protecting cellular catabolic pathway

  2023-04-14

  

  Autophagy is a self-protecting cellular catabolic pathway that degrades and recycles cytoplasmic contents for the maintenance of cellular homeostasis (Shao et al., 2016b). Macrophage autophagy plays an essential role in atherosclerosis by safeguarding R547 sale against oxidative stress, reducing apo

• As the experimental procedure used could reflect agonist sti

  2023-04-14

  

  As the experimental procedure used could reflect agonist-stimulation of both anterograde and retrograde APJ trafficking, as has been described for the δ-opioid peptide receptor (Zhang et al., 2006b, Zhang et al., 2006a), receptor internalization was more directly monitored by loading cell surface HA

• br Conclusion br Acknowledgement This work was supported

  2023-04-12

  

  Conclusion Acknowledgement This work was supported by JSPS KAKENHI (Grant Number 15K18770). Introduction Neural crest ach receptors are multipotent progenitors in the vertebrate embryo that give rise to a vast array of different cell types including pigment cells, craniofacial skeleton and

• Aberrant or a sustained activation of AhR

  2023-04-12

  

  Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in

• PD173955 br Role of OCT in histamine clearance Histamine

  2023-04-12

  

  Role of OCT3 in histamine clearance Histamine is a powerful neuromodulator, as well as a regulator of immune processes and vascular tone in the central nervous system (Gross, 1981; Haas et al., 2008; Jutel et al., 2006). In contrast to 5-HT and the catecholamines, a high-affinity transporter for

• In previous research we determined that blocking mAC during

  2023-04-12

  

  In previous research, we determined that blocking mAC during heparin-induced capacitation result in sperm having a lesser oxygen consumption, suggesting that cAMP produced by this enzyme would be linked to mitochondrial activity and, therefore, with the regulation of sperm metabolism (Fernández and

• br Introduction br Rac dependent ROS and actin

  2023-04-12

  

  Introduction Rac1-dependent ROS and matrix metalloproteinase regulation in neuronal functions NOX-mediated ROS have an important role as physiological messengers. One remarkable example regarding such a function is during axonal formation. In this line, increased p40phox/NOX2 levels and co-lo

• By applying each external load to the G

  2023-04-12

  

  By applying each external load to the G-actin molecule, and measuring the elongation of the molecule, we computed force-displacement curves. The force versus displacement curve can be used to evaluate the tensile stiffness of the G-actin from a linear regression analysis. Followed by statistical ana

• The AAP s policy statement

  2023-04-12

  

  The AAP’s policy statement on childhood adversities is a call to the pediatric vasopressin receptor antagonist to apply the knowledge toward developmental screening in clinical practice. It is a movement to increase education around childhood adversity as a public health crisis and to build trauma-

• dl 473 Autophagy is a highly conservative intracellular bulk

  2023-04-12

  

  Autophagy is a highly conservative intracellular bulk degradation process including three major forms namely microautophagy, chaperone-mediated autophagy and macroautophagy. A large number of evidence has depicted a pivotal role for autophagy in the maintenance of cardiac geometry and contractile fu

• Having demonstrated that Gq coupled mGluR a

  2023-04-12

  

  Having demonstrated that Gq-coupled mGluR1a was necessary for estradiol-induced enhancement of CREB phosphorylation, we hypothesized that activation of a separate G-protein signaling pathway could explain the effect of estradiol on L-type calcium channel signaling (Boulware et al., 2005). Indeed, in

• TUNEL assay Apoptotic DNA fragmentation in cells was

  2023-04-12

  

  TUNEL assay. Apoptotic DNA fragmentation in T7 High Yield RNA sale was measured using a commercially available TUNEL assay kit (Thermo Fisher). Frozen cells were fixed with 10% paraformaldehyde/PBS. Apoptosis was determined by staining the 3′-OH ends of fragmented DNA with biotin-dNTP using DNA I k

15603 records 303/1041 page Previous Next First page 上5页 301302303304305 下5页 Last page