• Targeted agents are also important in the treatment of advan

  2018-11-07

  

  Targeted agents are also important in the treatment of advanced melanoma. BRAF inhibitors (BRAFi), including the agents vemurafenib and dabrafenib, are beneficial in the population of melanoma patients whose tumors harbor a BRAF mutation. In a prospective randomized trial, the response rate to vemur

• The demonstration of intestinal dysbiosis following prolonge

  2018-11-07

  

  The demonstration of intestinal dysbiosis following prolonged exposure to antimicrobials (Mshvildadze et al., 2010) and the associated increased risk of NEC (Greenwood et al., 2014) in preterm infants indicates a potential role for antimicrobial therapy in the modification of the microbiome and subs

• The safety profile of CFZ used as a single agent

  2018-11-07

  

  The safety profile of CFZ used as a single agent for the treatment of relapsed and/or refractory MM was analyzed in a total of 526 patients enrolled in the four phase II clinical trials based on which the U.S. FDA approval was granted. The most severe side effects reported include: sudden death (wit

• br Materials and methods br

  2018-11-07

  

  Materials and methods Data availability The mass spectrometry datasets are publicly available from ProteomeXchange Consortium via the PRIDE partner repository (http://www.proteomexchange.org) with the dataset identifiers PXD001224 (GeLC–MSMS data) and PXD001088 (LC–MSMS data). Results obtained

• Numerical treatment For both O and CO diffusivities are iden

  2018-11-07

  

  Numerical treatment. For both O2 and CO2, diffusivities are identified by fitting a dedicated mathematical model to the experimental kinetic curve (space-dependent profile or time-dependent profile). This identification step is performed using a routine (“lsqnonlin”) of Matlab® software. Acknowle

• The more than two fold greater per occasion use

  2018-11-07

  

  The more than two-fold greater per occasion use of alcohol during adolescence than seen in adulthood is not only evident in humans (Hughes, 2010; Masten et al., 2009), but also in other mammalian bacteriological such as rodents (Doremus et al., 2005; Vetter et al., 2007). Consequently, rodent models

• Our results suggest coherence of temporal

  2018-11-07

  

  Our results suggest coherence of temporal encoding across timescales. In particular, we demonstrate rapid intertrial neural stability for encoding frequency information from 100 to 400Hz (for speech stimuli presented at 4.35Hz) relates to consistency of beat synchronization (to rates approximating s

• br Conclusions Neuroimaging studies of developmental and cli

  2018-11-07

  

  Conclusions Neuroimaging studies of developmental and clinical populations present several challenges and issues for consideration at the subject selection and data acquisition stage. Neuroimaging is expensive, amplifying the importance of obtaining the highest quality data, losing as little data

• The almost exclusive use of cardiac based measures of

  2018-11-07

  

  The almost exclusive use of cardiac-based measures of interoception reflects what is often an implicit assumption in the literature − that interoceptive sensitivity represents a unitary construct. It is assumed that those who exhibit a great deal of perceptual sensitivity for their heart rate will a

• Risk variants in KIAA and DCDC

  2018-11-07

  

  Risk variants in KIAA0319 and DCDC2 have recently been shown to interact with each other and to influence dyslexia phenotypes in a non-additive manner (Powers et al., 2013). This trans-genetic interaction between DCDC2 risk haplotypes and KIAA0319 risk haplotypes is based on the strong linkage diseq

• With the present study we aim

  2018-11-07

  

  With the present study we aim to clarify the trajectory of short-term recognition memory and sensorimotor gating throughout the complete period of adolescence, including pubertal time points, in male rats. In male rats a peripubertal period can be defined from ∼pd 38, shortly before the physiologica

• It is an over simplification to consider limbic

  2018-11-07

  

  It is an over-simplification to consider limbic and frontal Sulfo-NHS-LC-Biotin regions entirely separately, as there is significant cross-talk between these areas through fronto-limbic connections. Just this year, Cullen et al. (2016) used fMRI to examine the effect of SSRIs, including fluoxetine,

• br Conclusions Despite there has

  2018-11-06

  

  Conclusions Despite there has been an increased amount of research on “sustainable transportation”, most individual authors, entities, and agencies still do not have an agreed-upon definition of “sustainable transportation”. This poses challenges to the review of existing literature and to the pr

• br Case report A year

  2018-11-06

  

  Case report A 35-year-old female presented with fatty dyspepsia associated with recurrent postprandial abdominal distention without any pain, nausea, vomiting, jaundice, or fever. Physical examination showed no abdominal tenderness. Laboratory values, serum biochemistry, C-reactive protein and li

• In conclusion we have developed a

  2018-11-06

  

  In conclusion, we have developed a modified SILS technique to perform complex laparoscopic bariatric surgery. It is safe, technically feasible, reproducible, and minimally invasive, but the learning curve should be overcome to achieve better postoperative results. The results of the learning curve s

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