• br Materials and methods br Acknowledgements

  2018-10-20

  

  Materials and methods Acknowledgements We would like to thank Michael Majurski, Jing Gao, and Mylene Simon for data processing and web application development. We would also like to thank Steven Lund and James Filliben for help with statistical analysis. MH acknowledges support from the ISAC S

• br Nonhuman primate models for transplantation therapy motor

  2018-10-20

  

  Nonhuman primate models for transplantation therapy: motor and non-motor manifestations of the MPTP lesion Methods that have been used to induce a parkinsonian state in NHPs include 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) administration (Emborg, 2007), 6-hydroxydopamine administration

• Also critical to the success of hard tissue engineering stra

  2018-10-20

  

  Also critical to the success of hard tissue engineering strategies is the selection and use of an appropriate growth factor regimen. Although several growth factors are reported to play an important role in the process of matrix mineralisation, IGF-1 is the most abundant growth factor in bone matrix

• br Experimental Procedures br Acknowledgments The authors

  2018-10-20

  

  Experimental Procedures Acknowledgments The authors would like to thank Birgit Linder and Ann-Marie Alborn for excellent technical assistance and the Center for Cellular Imaging and the Electron Microscopy Unit at Gothenburg University for their technical support. The authors would also like t

• In the adult mouse and

  2018-10-20

  

  In the adult mouse and human lungs, distinct region-specific epithelial progenitor cells have been described (Wansleeben et al., 2013), but their fetal counterparts remain undercharacterized. At E10.5–E12.5, Id2-expressing distal tip cells of the fetal lung buds are multipotent and contribute to the

• The network shared among L TD OCT SOX and

  2018-10-20

  

  The network shared among L1TD1, OCT4, SOX2, and NANOG is highly interesting. Our analysis suggests that the nuclear epigenetic regulator PARP1 and CDK1 are key proteins in the core pluripotency network. Recently, PARP1 expression and PARylation activity were shown to be increased in undifferentiated

• br Experimental Procedures Extended details outlining specif

  2018-10-20

  

  Experimental Procedures Extended details outlining specific steps and protocols can be found in the Supplemental Experimental Procedures. Author Contributions Acknowledgments Introduction Proximal spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by t

• br Results br Discussion GRM may be associated with

  2018-10-20

  

  Results Discussion GRM7 may be associated with rgd peptide developmental disorders, including ADHD (Elia et al., 2012) and ASD (Yang and Pan, 2013). However, there is no direct evidence regarding whether or how GRM7 regulates brain development and neurogenesis. Neurogenesis in the developing b

• Our objective was to determine

  2018-10-20

  

  Our objective was to determine how the culturing of CD34+ prostaglandin receptor under conditions that influence ARNT complex formation might affect the expansion of HSPCs. We hypothesized that the use of culture conditions that stabilize HIF-1α and antagonize the AhR protein would promote the expa

• In contrast the in vitro studies demonstrate that blocking

  2018-10-20

  

  In contrast, the in vitro studies demonstrate that blocking P-Cad during a pre-incubation period prior to clonal plating had a detrimental effect on the formation of retinal spheres from single RSCs; even though they proliferated in the absence of antibody. However, we were unable to completely bloc

• TAU fragments carry an apoptosis

  2018-10-20

  

  TAU fragments carry an apoptosis-inducing activity, which is further potentiated when orexin agonist are exposed to TAU fragments carrying the N279K mutation (Fasulo et al., 2005). In addition, overexpression of full-length TAU carrying the N279K or the V337M mutation resulted in induction of apopt

• GDC-0152 br Discussion However it is important

  2018-10-20

  

  Discussion However, it is important to note that a number of studies have demonstrated that iPS cell lines derived from skin biopsies typically harbor a unique subset of de novo genetic abnormalities, either in the form of copy-number variation or single base-pair changes (Abyzov et al., 2012; Go

• O4I1 manufacturer Our initial endeavors in characterizing ou

  2018-10-20

  

  Our initial endeavors in characterizing our isogenic iPSCs lines included a microarray-based large-scale gene O4I1 manufacturer analysis comparing the HD iPSCs with the corrected line C116 iPSCs (An et al., 2012). These studies were restricted to a comparison of only the iPSCs lines but yielded seve

• The fact that the in

  2018-10-20

  

  The fact that the in vitro induction of osteogenic differentiation leads to sarcoma development from sarcoma iPSCs in concert with EWS-FLI1 expression indicates that these sarcomas arise from osteogenic progenitor cells. However, it is important to note that the withdrawal of EWS-FLI1 in osteosarcom

• beta-lactamase Another question is the heterogeneity within

  2018-10-20

  

  Another question is the heterogeneity within and between organoids, which seems common to all the protocols developed so far but has not yet been studied in detail. Several processes, such as progenitor proliferation, cell differentiation, and ontogenetic cell death, could be potential sources of or

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