• Alternative approaches to LV are non viral

  2018-10-24

  

  Alternative approaches to LV are non-viral vectors such as RNA or DNA, which are considered safer due to their integration-free nature (Hardee et al., 2017). However, manufacturing RNA is expensive and difficult because RNA has a propensity to degrade (Yin et al., 2014). On the other hand, DNA plasm

• Raman microspectroscopy is a marker free method

  2018-10-24

  

  Raman microspectroscopy is a marker-free method that can be used to characterize single cells based on a pattern of molecular vibrational modes, which reflects the composition of intracellular proteins, lipids, nucleic acids, and glucagon receptor (Puppels et al., 1990). Notingher et al. (2004) inv

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We wish to thank Nicole Varain and Donna Colon for their excellent technical support assisting with the fetal sheep transplants. This work was supported by NIH, NHLBIR01HL097623, and the Intramural Pilot Program of Wake Forest Sch

• Active cell proliferation is key for transcription factor in

  2018-10-24

  

  Active cell proliferation is key for transcription factor-induced cell-fate change during cellular reprogramming. Because acute leukemias barely or do not proliferate in vitro, we endeavored to reprogram leukemic B cell lines as well as MLL-rearranged primary blasts induced to proliferate through xe

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We appreciate the expert technical assistance of N. Hayashi, K. Iseki, T. Hashiguchi, W. Ohashi, M. Kawahara, S. Okamoto, and C. Yamada (Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe). We appre

• Introduction The mammalian respiratory tract is normally mai

  2018-10-24

  

  Introduction The mammalian respiratory tract is normally maintained by abundant progenitors that differ in molecular phenotype, differentiation potential, and regulation between airway regions along the proximodistal axis (Hogan et al., 2014; Rackley and Stripp, 2012). Basal cells maintain the pseu

• Such spontaneous Ca transients have

  2018-10-24

  

  Such spontaneous Ca2+ transients have been reported in postnatal mouse cochlear supporting cells (Tritsch et al., 2007), and the Ca2+ signals were suggested to be propagated via gap junctions and hemichannels containing CX26 and CX30 (Anselmi et al., 2008; Schutz et al., 2010). It was also suggested

• To learn what specific genes and biological pathways are

  2018-10-24

  

  To learn what specific genes and biological pathways are involved in the response to pro-oxidant exposure, we performed RNA-seq analysis on 72-hpf embryos after 48 hr of pro-oxidant exposure; the heatmap analysis of unsupervised clustering is shown in Figure 3D. We found 316 genes upregulated (incre

• Fulvestrant While all of the original and

  2018-10-24

  

  While all of the original and refined conventional conditions appear to support primary germ cell populations derived from testes of neonatal or prepubertal pups in which at least some SSCs persist for various periods of time, the impacts of the conditions on derivation and long-term maintenance of

• There is a fast growing interest in

  2018-10-24

  

  There is a fast-growing interest in microglia, as they are increasingly implicated in neurodegenerative disease, neurodevelopmental disorders, and in neuropathic pain. Our iPSC microglia transcribe key Amyloid β-Peptide (1-42) involved in AD, PD, and MND. Several other disease-associated genes, incl

• Measurements of light hadrons produced in heavy ion collisio

  2018-10-24

  

  Measurements of light hadrons produced in heavy ion collisions at RHIC energies indeed indicated the suppression of hadron production by over a factor of five in central Au+Au collisions [6]. Meanwhile, no suppression was observed for the same hadrons and high-energy direct photons in case of d+Au c

• As a comparison Fig d

  2018-10-24

  

  As a comparison, Fig. 2d shows the shape of the curve for the probe approaching the measured sample (curve 2) for the case when the standard system for detecting the position of the probe tip is used. This system is based on the principle of registering the position of the laser beam reflected from

• br Conclusions br Ethics approval br Acknowledgements

  2018-10-24

  

  Conclusions Ethics approval Acknowledgements Background Human experience takes place in multiple overlapping contexts, including geographic contexts such as neighborhoods and cities, organizational contexts such as schools and clinics, and social contexts such as haspin inhibitor and fr

• Third in the context of unemployment and physical

  2018-10-24

  

  Third, in the context of unemployment and physical activity gender is important. While women appear to be able to take advantage of the reduction in labor supply that accompanies unemployment to invest time in health through physical activity, consistent with the Grossman model of health capital, th

• This evidence is in line with previous empirical

  2018-10-24

  

  This evidence is in line with previous empirical investigations conducted on the UK with BHPS data by Giordano and Lindström (2011) and Lindström and Giordano (2016) which use active participation in associations as structural social capital and an index of self-rated psychological health obtained f

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